Tafenoquine is a pharmaceutical substance with the name tafenoquine and CAS number 106635-80-7. It is an antimalarial drug used for the prevention and treatment of malaria caused by Plasmodium vivax parasites. Tafenoquine belongs to the class of drugs known as 8-aminoquinolines and works by interfering with the growth and reproduction of the parasites.

Tafenoquine is primarily used as a prophylactic treatment for individuals traveling to areas where P. vivax malaria is endemic. It is also used as a radical cure for patients diagnosed with P. vivax malaria to prevent relapse. Tafenoquine is administered orally in tablet form, and its long half-life allows for less frequent dosing compared to other antimalarial drugs.

Although tafenoquine has proven to be effective against P. vivax malaria, it may cause some adverse effects. Common side effects include headache, dizziness, nausea, vomiting, and abdominal pain. In rare cases, it can cause hemolytic anemia or severe psychiatric symptoms, such as anxiety and dep