NEPAFENAC (PhEur)

Nepafenac is a pharmaceutical substance that is primarily used as a nonsteroidal anti-inflammatory drug (NSAID). It is commonly prescribed for the treatment of pain and inflammation in the eye after cataract surgery.

Nepafenac is chemically known as 2-amino-3-benzoylbenzeneacetamide and is represented by its CAS number 78281-72-8. It is a prodrug, meaning it is converted into its active form, amfenac, in the eye. Amfenac works by inhibiting the production of inflammatory enzymes called cyclooxygenases, thereby reducing swelling and pain.

As an ophthalmic solution, nepafenac is typically administered as eye drops. It is usually recommended to instill one drop into the affected eye(s) three times a day, starting one day prior to cataract surgery and continuing for two weeks after surgery.

Common side effects of nepafenac may include temporary eye discomfort, blurred vision, itching, redness, and a feeling of something being in the eye. Serious side effects such as eye infections or allergic reactions are ra