Name: Pyrimethamine
CAS number: 58-14-0

Pyrimethamine is a pharmaceutical substance that belongs to the class of antiparasitic drugs. It is primarily used in the prevention and treatment of malaria infections caused by Plasmodium falciparum. Pyrimethamine is a white crystalline powder that is odorless and insoluble in water.

As a pharmaceutical substance, pyrimethamine acts by inhibiting the enzyme dihydrofolate reductase, which is essential for the synthesis of pyrimidine, a building block of DNA in parasites like Plasmodium. By interfering with this enzyme, pyrimethamine disrupts the production of DNA and RNA, ultimately leading to the death of the parasite.

Pyrimethamine is usually administered orally in tablet form or as an injectable solution. The dosage and duration of treatment may vary depending on the severity of the infection and the patient’s age and weight. It is often prescribed in combination with other antimalarial drugs, such as sulfadoxine, to enhance its effectiveness and prevent the deve