Chloroquine, also known by its CAS number 54-05-7, is a pharmaceutical substance primarily used for its antimalarial properties. It belongs to the class of 4-aminoquinoline compounds and is widely used in the prevention and treatment of malaria, caused by Plasmodium species.
This pharmaceutical substance works by interfering with the growth and reproduction of the parasites in the red blood cells. Chloroquine inhibits heme polymerase enzyme, resulting in the accumulation of toxic heme metabolites within the parasites. This accumulation ultimately leads to the death of the parasites, thereby reducing the severity and duration of malarial infections.
In addition to its antimalarial effects, chloroquine also exhibits immunomodulatory and anti-inflammatory properties. It has been used to treat certain autoimmune diseases, such as rheumatoid arthritis and lupus erythematosus, by reducing the production and release of pro-inflammatory cytokines.
Chloroquine is available in various formulations, including tablets