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Product: Artesunate CAS Number: 88495-63-0 Artesunate is a pharmaceutical substance used in the treatment of malaria, specifically for the treatment of severe cases or cases resistant to other antimalarial drugs. It belongs to the class of artemisinin derivatives, which are derived from the Chinese herb Artemisia annua. Artesunate exhibits potent antimalarial activity by specifically targeting the Plasmodium parasite responsible for causing malaria. It works by interfering with the parasite's ability to reproduce and spread, ultimately leading to its death. This mechanism of action makes it effective against both the blood stage and the dormant liver stage of the parasite. As a pharmaceutical substance, artesunate is typically administered through injection or oral tablets. It is rapidly absorbed and converted into its active form, dihydroartemisinin, in the body. The substance has a relatively short half-life, necessitating multiple dosages to ensure adequate therapeutic levels. -
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Arterolane, also known as OZ277, is a pharmaceutical substance that is used in the treatment of malaria. Its CAS number is 664338-39-0. Arterolane belongs to the class of antimalarial drugs known as arylaminoalcohols. It works by inhibiting the growth and replication of the Plasmodium parasite responsible for causing malaria. Arterolane is highly effective against both drug-sensitive and drug-resistant strains of Plasmodium falciparum, the most deadly species of malaria parasite. It is commonly used in combination therapy with another antimalarial drug called piperaquine to improve treatment outcomes and prevent the development of drug resistance. Arterolane has a relatively short half-life in the body, allowing for once-daily dosing. It is generally well-tolerated, with mild and transient side effects such as headache, nausea, and dizziness being reported. As an important tool in the fight against malaria, arterolane demonstrates promising results in clinical trials and is being utilized in various malar -
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Artenimol, also known as dihydroartemisinin (CAS number: 71939-50-9), is a pharmaceutical substance used in the treatment of malaria. It is derived from the Chinese herb Artemisia annua and belongs to the artemisinin class of antimalarial agents. Artenimol acts by rapidly killing the malaria parasites in the blood, making it highly effective in the treatment of both uncomplicated and severe cases of malaria. Its mechanism of action involves the production of reactive oxygen species, which cause oxidative stress and damage to the parasite's cell structures. Artenimol is typically administered in combination with other antimalarial drugs to prevent the development of drug resistance. -
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Artemotil (CAS - 75887-54 beta-arteether) is an antimalarial artemisinin derivative, approved for the treatment of severe cases of P. falciparum malaria. The mixture of artemotil and alpha-arteether is used in patients with cerebral malaria. Most of the artemisinin compounds including artemotil are metabolized into dihydroartemisinin, which is responsible for antimalarial activity. These compounds contain stable endoperoxide bridge. The antimalarial activity of the drug thus is dependent on the cleavage of the endoperoxide by intraparasitic heme. The cleaved endoperoxide ultimately becomes a carbon centered free radical, which then functions as an alkylating agent, reacting with both heme and parasitic proteins (but not DNA). In P. falciparum, one of the principal alkylation target is the translationally controlled tumor protein (DHA-TCTP) homolog. Some intraparasitic TCTP is situated in the membrane surrounding the heme-rich food vacuole, where heme could catalyse the formation of drug-protein (DHA-TCTP) -
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Artemisinin, with the CAS number 63968-64-9, is a naturally occurring compound derived from the plant Artemisia annua, also known as sweet wormwood or annual wormwood. It is a sesquiterpene lactone with a unique chemical structure and possesses antimalarial properties. Artemisinin has been used for centuries in traditional Chinese medicine as a treatment for fever and malaria. However, its full potential as an effective antimalarial drug was realized in the 1970s by Chinese scientist Tu Youyou, who was awarded the Nobel Prize in Physiology or Medicine in 2015 for her work on artemisinin. This pharmaceutical substance works by interacting with iron and forming reactive oxygen species inside the malaria parasite, leading to its destruction. As a result, artemisinin and its derivatives are considered first-line treatments for uncomplicated malaria, particularly for chloroquine-resistant strains. Artemisinin-based combination therapies (ACTs) are currently recommended by the World Health Organization (WHO) as -
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Artemether, with the Chemical Abstract Service (CAS) number 71963-77-4, is a pharmaceutical substance used primarily in the treatment of malaria. It is a synthetic derivative of artemisinin, a compound derived from the Chinese herb Artemisia annua. Artemether is classified as an antimalarial agent and belongs to the class of artemisinin-based combination therapies (ACTs). Artemether is available in various pharmaceutical forms, including oral tablets and injection formulations. It is rapidly absorbed and converted into its active metabolite dihydroartemisinin in the body. This metabolite works by interacting with the heme moiety of hemoglobin, leading to the generation of toxic free radicals within malaria parasites, ultimately resulting in their destruction. As a highly effective antimalarial, artemether is recommended for uncomplicated malaria caused by Plasmodium falciparum. It is often used in combination with other antimalarial drugs, such as lumefantrine, to maximize efficacy and reduce the risk of re -
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Apremilast is a pharmaceutical substance with the chemical name N-[2-[1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-1,3-dioxoisoindolin-4-yl]acetamide. Its CAS number is 608141-41-9. Apremilast is a small molecule inhibitor of phosphodiesterase 4 (PDE4), an enzyme that plays a role in the regulation of inflammation. It is primarily used as a treatment for certain autoimmune diseases, such as psoriasis and psoriatic arthritis. The substance works by inhibiting the production of certain pro-inflammatory mediators, such as tumor necrosis factor-alpha (TNF-a), interleukin-17 (IL-17), and interleukin-23 (IL-23). By reducing the levels of these mediators, it helps to suppress the autoimmune response and alleviate symptoms associated with chronic inflammation. Apremilast is available in oral tablet form and is usually taken once or twice daily, as prescribed by a healthcare professional. It may take several weeks for the full therapeutic effects to be observed. As with any medication, apremilast may caus -
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APABETALONE, also known as RVX-208, is a pharmaceutical substance that has been developed for the treatment of various cardiovascular conditions. Its chemical name is 4-(1-(4-fluorophenyl)-5-(3-(4-fluorophenyl)-1H-pyrazol-1-yl)-, 2H-thieno(3,2-b)pyridin-7-yl)butanoic acid. The CAS number for APABETALONE is 1044870-39-4. It works by modulating certain genes involved in lipid metabolism, resulting in the increase of high-density lipoprotein (HDL) cholesterol levels. APABETALONE has shown potential in clinical trials for its ability to reduce atherosclerosis and improve cardiovascular outcomes. It has also demonstrated anti-inflammatory effects and has been investigated as a potential treatment for other inflammatory disorders. Further research and clinical trials are necessary to fully understand the safety and efficacy of APABETALONE in different patient populations and indications. -
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Amodiaquine, also known by its CAS number 86-42-0, is a pharmaceutical substance used for the treatment of malaria. It belongs to the class of antimalarial drugs and is commonly used in combination with other medications to increase its effectiveness. Amodiaquine works by interfering with the growth and replication of the malaria parasite, thus helping to eliminate the infection from the body. It is available in various forms such as tablets, capsules, and syrups for oral administration. Amodiaquine is a crucial component in the global efforts to combat malaria, particularly in regions where the disease is prevalent.
