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Sulfalene is a pharmaceutical substance with the chemical name N-(4-aminophenyl)benzenesulfonamide. It is also known by its CAS number, which is 152-47-6. Sulfalene belongs to the class of sulfonamide antibiotics and is used for the treatment of various bacterial infections. It works by inhibiting the growth and reproduction of bacteria by interfering with their metabolic processes. As a sulfonamide, sulfalene acts by inhibiting the synthesis of folic acid, which is essential for the growth and survival of bacteria. By interfering with folic acid synthesis, sulfalene effectively stops the bacteria from multiplying and spreading. Sulfalene is mainly prescribed for the treatment of urinary tract infections caused by susceptible bacteria. It may also be used to treat other types of infections, such as respiratory tract infections, skin and soft tissue infections, and certain sexually transmitted infections. It is available in various dosage forms, including tablets and suspension, and is typically administer -
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Proguanil, also known by its CAS number 500-92-5, is a pharmaceutical substance used for the prevention and treatment of malaria. It is a derivative of the antimalarial drug atovaquone. Proguanil functions as a prodrug, meaning it is metabolized in the body to its active form, cycloguanil, which inhibits the parasite's ability to synthesize nucleic acids. This disruption ultimately leads to the death of the malaria parasite. Proguanil is available in various formulations, including tablets, which are commonly used for prophylaxis, and combination products with atovaquone for treatment. It is considered an essential medication for the prevention and management of malaria in many regions of the world. -
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Arterolane, also known as OZ277, is a pharmaceutical substance that is used in the treatment of malaria. Its CAS number is 664338-39-0. Arterolane belongs to the class of antimalarial drugs known as arylaminoalcohols. It works by inhibiting the growth and replication of the Plasmodium parasite responsible for causing malaria. Arterolane is highly effective against both drug-sensitive and drug-resistant strains of Plasmodium falciparum, the most deadly species of malaria parasite. It is commonly used in combination therapy with another antimalarial drug called piperaquine to improve treatment outcomes and prevent the development of drug resistance. Arterolane has a relatively short half-life in the body, allowing for once-daily dosing. It is generally well-tolerated, with mild and transient side effects such as headache, nausea, and dizziness being reported. As an important tool in the fight against malaria, arterolane demonstrates promising results in clinical trials and is being utilized in various malar -
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Artemotil (CAS - 75887-54 beta-arteether) is an antimalarial artemisinin derivative, approved for the treatment of severe cases of P. falciparum malaria. The mixture of artemotil and alpha-arteether is used in patients with cerebral malaria. Most of the artemisinin compounds including artemotil are metabolized into dihydroartemisinin, which is responsible for antimalarial activity. These compounds contain stable endoperoxide bridge. The antimalarial activity of the drug thus is dependent on the cleavage of the endoperoxide by intraparasitic heme. The cleaved endoperoxide ultimately becomes a carbon centered free radical, which then functions as an alkylating agent, reacting with both heme and parasitic proteins (but not DNA). In P. falciparum, one of the principal alkylation target is the translationally controlled tumor protein (DHA-TCTP) homolog. Some intraparasitic TCTP is situated in the membrane surrounding the heme-rich food vacuole, where heme could catalyse the formation of drug-protein (DHA-TCTP) -
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Product: Artesunate CAS Number: 88495-63-0 Artesunate is a pharmaceutical substance used in the treatment of malaria, specifically for the treatment of severe cases or cases resistant to other antimalarial drugs. It belongs to the class of artemisinin derivatives, which are derived from the Chinese herb Artemisia annua. Artesunate exhibits potent antimalarial activity by specifically targeting the Plasmodium parasite responsible for causing malaria. It works by interfering with the parasite's ability to reproduce and spread, ultimately leading to its death. This mechanism of action makes it effective against both the blood stage and the dormant liver stage of the parasite. As a pharmaceutical substance, artesunate is typically administered through injection or oral tablets. It is rapidly absorbed and converted into its active form, dihydroartemisinin, in the body. The substance has a relatively short half-life, necessitating multiple dosages to ensure adequate therapeutic levels. -
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Hydroxychloroquine, also known by its CAS number 118-42-3, is a pharmaceutical substance primarily used to treat malaria, rheumatoid arthritis, and lupus erythematosus. It belongs to the class of medications known as antimalarials and is derived from the closely related drug chloroquine. Hydroxychloroquine works by interfering with the growth and reproduction of parasites, thereby preventing the spread of malaria within the body. Additionally, it exhibits immunomodulatory properties that help control autoimmune diseases like rheumatoid arthritis and lupus erythematosus. This pharmaceutical substance is available in oral tablet or suspension form, providing a safe and effective treatment option for various medical conditions. -
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Halofantrine, with CAS number 69756-53-2, is a pharmaceutical substance used for the treatment of malaria. It belongs to the class of antimalarial agents and is primarily used to treat infections caused by Plasmodium falciparum, which is a severe and potentially fatal form of malaria. Halofantrine is available in tablet form and is administered orally. It works by targeting the parasite's ability to reproduce and survive in the body. The substance interferes with the formation of hemozoin, a toxic byproduct of hemoglobin digestion by the parasites, leading to their death. While halofantrine has shown effectiveness in treating malaria, it is recommended to be used cautiously due to its potential side effects. Common side effects may include gastrointestinal discomfort, vomiting, and dizziness. It may also cause cardiac complications, such as QT prolongation, which can lead to abnormal heart rhythms. As with any pharmaceutical substance, it is important to carefully follow the prescribed dosage and duration -
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Chloroquine, also known by its CAS number 54-05-7, is a pharmaceutical substance primarily used for its antimalarial properties. It belongs to the class of 4-aminoquinoline compounds and is widely used in the prevention and treatment of malaria, caused by Plasmodium species. This pharmaceutical substance works by interfering with the growth and reproduction of the parasites in the red blood cells. Chloroquine inhibits heme polymerase enzyme, resulting in the accumulation of toxic heme metabolites within the parasites. This accumulation ultimately leads to the death of the parasites, thereby reducing the severity and duration of malarial infections. In addition to its antimalarial effects, chloroquine also exhibits immunomodulatory and anti-inflammatory properties. It has been used to treat certain autoimmune diseases, such as rheumatoid arthritis and lupus erythematosus, by reducing the production and release of pro-inflammatory cytokines. Chloroquine is available in various formulations, including tablets -
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Artemether, with the Chemical Abstract Service (CAS) number 71963-77-4, is a pharmaceutical substance used primarily in the treatment of malaria. It is a synthetic derivative of artemisinin, a compound derived from the Chinese herb Artemisia annua. Artemether is classified as an antimalarial agent and belongs to the class of artemisinin-based combination therapies (ACTs). Artemether is available in various pharmaceutical forms, including oral tablets and injection formulations. It is rapidly absorbed and converted into its active metabolite dihydroartemisinin in the body. This metabolite works by interacting with the heme moiety of hemoglobin, leading to the generation of toxic free radicals within malaria parasites, ultimately resulting in their destruction. As a highly effective antimalarial, artemether is recommended for uncomplicated malaria caused by Plasmodium falciparum. It is often used in combination with other antimalarial drugs, such as lumefantrine, to maximize efficacy and reduce the risk of re
